⏳ Category
Anti-Aging & Longevity Peptides
Compounds studied for cellular repair, telomere maintenance, and longevity pathways. Most evidence here is early-stage or preclinical.
Compounds studied for cellular repair, telomere maintenance, and longevity pathways. Most evidence here is early-stage or preclinical.
"Anti-aging" peptides target the biology of aging rather than a single disease — telomere maintenance, mitochondrial function, cellular senescence, and tissue-specific repair signaling. The science here is genuinely exciting but far earlier-stage than the marketing suggests: most of these compounds have evidence only in cells and animals, and a few rest largely on research from a single group.
The category includes telomerase-linked peptides (epitalon), mitochondrial-derived peptides (humanin, MOTS-c), the mitochondria-targeting drug-candidate SS-31/elamipretide, the senolytic FOXO4-DRI, and the Russian "bioregulator" short peptides. With the exception of compounds in formal clinical trials, none is an approved anti-aging therapy, and human longevity claims are not established.
A naturally occurring copper-binding tripeptide that declines with age and is widely used in cosmetic skincare for its collagen and skin-repair signaling.
Read the guide →A selective growth-hormone secretagogue (a ghrelin-receptor agonist) studied for stimulating the body's own GH release with relatively few off-target effects.
Read the guide →A growth-hormone-releasing hormone (GHRH) analog engineered for a longer half-life, studied for sustained elevation of GH and IGF-1.
Read the guide →A synthetic tetrapeptide developed in Russia and researched for telomerase activation, pineal gland regulation, and longevity — largely in early and animal studies.
Read the guide →A mitochondrial-derived peptide studied as a metabolic regulator and “exercise mimetic,” with effects on insulin sensitivity in animal models.
Read the guide →A GHRH analog (the first 29 amino acids of GHRH) historically FDA-approved for assessing growth-hormone secretion, now commonly compounded for “anti-aging” use.
Read the guide →A thymus-derived peptide preparation studied — largely in Russia — for restoring immune balance and as part of peptide bioregulation research on aging.
Read the guide →A mitochondria-targeting tetrapeptide that binds cardiolipin to support mitochondrial function, studied (as elamipretide) for mitochondrial diseases, heart failure, and certain eye conditions.
Read the guide →A mitochondrial-derived peptide with cytoprotective properties, studied for neuroprotection (including Alzheimer's models), metabolism, and links to longevity.
Read the guide →A short “peptide bioregulator” (Glu-Asp-Arg) from the Khavinson research line, studied for brain function, neuroprotection, and age-related decline.
Read the guide →A recombinant fragment of parathyroid hormone (PTH 1–34) and FDA-approved anabolic drug (Forteo) that builds new bone in people with osteoporosis at high fracture risk.
Read the guide →An experimental “senolytic” peptide designed to selectively kill senescent (aged, non-dividing) cells, famous for a mouse study showing restored fitness — but entirely preclinical.
Read the guide →A short “peptide bioregulator” (Lys-Glu-Asp) from the Khavinson research line, proposed to support the vascular system and studied mainly in Russian models.
Read the guide →A short “peptide bioregulator” (Ala-Glu-Asp-Arg) from the Khavinson research line, proposed to support cardiac tissue and studied mainly in Russian models.
Read the guide →A PTH-related protein analog and FDA-approved anabolic drug (Tymlos) that stimulates new bone formation in people with osteoporosis at high fracture risk.
Read the guide →A peptide hormone that lowers blood calcium and slows bone breakdown; the salmon form (Miacalcin, Fortical) is FDA-approved for osteoporosis, Paget's disease, and hypercalcemia.
Read the guide →The body's “master antioxidant” — a naturally occurring tripeptide central to cellular defense, studied for oxidative stress, immune function, metabolic health, and (controversially) skin lightening.
Read the guide →A dipeptide concentrated in muscle and brain, studied for buffering exercise fatigue, anti-glycation, and antioxidant effects — though muscle levels are usually raised through its precursor, beta-alanine.
Read the guide →No peptide has been shown to reverse human aging in rigorous clinical trials. The most striking results (for example, senescent-cell clearance with FOXO4-DRI) come from mouse studies, which often do not translate to people.
Most are unapproved research chemicals with preclinical evidence only. A few, like SS-31 (elamipretide), are genuine investigational drugs in clinical trials, but with mixed results and no broad approval.
These are ultra-short synthetic peptides (such as epitalon, vesugen, cardiogen and pinealon) developed mainly in Russia, each proposed to act on a specific tissue by influencing gene expression. The evidence is largely preclinical and from the originating research groups, with little independent replication.